Table 2.
Time trends for missense mutations in spike protein.
| Spike Mutation | Frequency in Analyzed Dataset n = 1106 | OR | 95% CI | p | |||
|---|---|---|---|---|---|---|---|
| Nov 20 | Dec 20 | Jan 21 | Feb 21 | ||||
| delH69V70 | 30 (26.31%) | 47 (29.19%) | 110 (24.66%) | 94 (60.65%) | 1.54 | 1.30–1.83 | <0.0001 |
| delY144 | 0 | 2 (1.23%) | 43 (9.75%) | 78 (51.32%) | 9.52 | 6.46–14.35 | <0.0001 |
| P681H | 1 (0.88%) | 15 (9.20%) | 110 (24.66%) | 93 (60.00%) | 4.30 | 3.32–5.67 | <0.0001 |
| T716I | 0 | 1 (0.88%) | 43 (9.64%) | 80 (51.61%) | 10.59 | 7.13–16.11 | <0.0001 |
| S982A | 0 | 1 (0.88%) | 43 (9.64%) | 79 (50.97%) | 10.35 | 6.97–15.72 | <0.0001 |
| A570D | 0 | 1 (0.88%) | 43 (9.64%) | 78 (51.32%) | 10.12 | 6.83–15.37 | <0.0001 |
| N501Y | 0 | 1 (0.88%) | 43 (9.64%) | 78 (51.32%) | 10.12 | 6.83–15.37 | <0.0001 |
| D1118H | 0 | 1 (0.88%) | 43 (9.64%) | 77 (49.68%) | 9.90 | 6.68–15.01 | <0.0001 |
| N439K | 30 (26.31%) | 47 (29.19%) | 76 (17.23%) | 17 (10.97%) | 0.68 | 0.57–0.82 | <0.0001 |
ΔH69V70 was found in lineage B.1.1.7 (Clade 1), and in B.1.258 (Clade 2). ΔY144, T716I, S982A, A570D, N501Y, and D1118H was a signature mutation of B.1.1.7 (Clade 1) lineage. P681H was related to B.1.1.7 and B.1.1.29 (Clade 1) lineages. Finally, N439K persisted in the B.1.258 (Clade 2) lineage.