Table 2B:

Prevalence of chronic health conditions of survivors of AML treated with conventional therapy (n=67) and community controls (N=450) ^*

Cardiovascular		Cardiomyopathy					Hypertension					Hypertriglyceridemia						High Cholesterol
		Survivors		Controls			Survivors		Controls			Survivors		Controls				Survivors		Controls
		N	%	N	%	P	N	%	N	%	P	N	%	N	%	p		N	%	N	%	p
	Normal	59	88.1	438	97.3	0.001	31	46.3	251	55.7	0.05	56	83.6	368	81.7	0.57		51	76.1	311	69.1	0.69
	Grade 1	-	-	-	-		22	32.8	145	32.2		9	13.4	68	15.1			14	20.9	120	26.6
	Grade 2	6	8.9	10	2.2		10	14.9	43	9.5		1	1.5	12	2.6			2	3.0	19	4.2
	Grade 3	2	3.0	2	0.4		4	6.0	11	2.4		1	1.5	2	0.4			0	0	0	0
	Grade 4	0	0	0	0		0	0	0	0		0	0	0	0			0	0	0	0
Endocrine/ Metabolic		Growth Hormone Deficiency					Primary Hypothyroidism					Abnormal Glucose Metabolism						Obesity
		Survivors		Controls			Survivors		Controls			Survivors		Controls				Survivors		Controls
		N	%	N	%		N	%	N	%		N	%	N	%			N	%	N	%	0.16
	Normal	65	97.0	442	98.2	0.50	63	94.0	432	96.0	0.67	54	80.6	378	84.0	0.35		18	26.8	172	38.2
	Grade 1	2	3.0	8	1.7		0	0	1	0.2		8	11.9	57	12.6			-	-	-	-
	Grade 2	0	0	0	0		4	6.0	17	3.7		4	6.0	13	2.8			21	31.3	119	26.4
	Grade 3	-	-	-	-		0	0	0	0		1	1.5	2	0.4			22	32.8	121	26.8
	Grade 4	-	-	-	-		0	0	0	0		0	0	0	0			6	8.9	38	8.4
Reproductive		Leydig Cell Insufficiency (Male)					Premature Ovarian Failure (Female)					Abnormal Sperm Concentration‡						Liver Fibrosis
		Survivors		Controls			Survivors		Controls			Survivors		Controls†			Gastrointestinal	Survivors		Controls†
		N	%	N	%		N	%	N	%		N	%	N	%			N	%	N	%
	Normal	25	100	186	93.0	0.10	42	100	249	99.6	0.97	2	66.7	-	-			59	88.0	-	-
	Grade 1	0	0	10	5.0		-	-	-	-		-	-	-	-			1	1.5	-	-
	Grade 2	0	0	4	2.0		-	-	-	-		0	0	-	-			0	0	-	-
	Grade 3	0	0	0	0		0	0	1	0.4		1	33.3	-	-			6	8.9	-	-
	Grade 4	-	-	-	-		-	-	-	-		-	-	-	-			1	1.5	-	-
		Abnormal FEV1					Abnormal DLCOcorr					Abnormal TLC						Cataract
		Survivors		Controls			Survivors		Controls			Survivors		Controls				Survivors		Controls
Pulmonary		N	%	N	%		N	%	N	%		N	%	N	%		Ocular	N	%	N	%
	Normal	60	89.5	413	91.8		61	91.0	431	95.8	0.01	66	98.5	440	97.7	0.99		63	94.0	428	95.1	0.86
	Grade 1	6	8.9	22	4.9		1	1.5	17	3.8		1	1.5	9	2.0			4	6.0	19	4.2
	Grade 2	0	0	11	2.4	0.61	5	7.5	1	0.2		0	0	1	0.2			0	0	2	0.4
	Grade 3	1	1.5	3	0.7		0	0	1	0.2		0	0	0	0			0	0	1	0.2
	Grade 4	0	0	1	0.2		-	-	-	-		-	-	-	-			0	0	0	0
		Low Bone Mineral Density					Osteonecrosis					Motor Neuropathy						Sensory Neuropathy
		Survivors		Controls†			Survivors		Controls†			Survivors		Controls				Survivors		Controls
Bone Health		N	%	N	%		N	%	N	%	Neurology	N	%	N	%			N	%	N	%
	Normal	38	56.7	-	-		66	98.5	-	-		61	91.0	450	100	0.10		48	71.6	415	92.2	<0.001
	Grade 1	22	32.8	-	-		1	1.5	-	-		2	3.0	0	0			16	23.9	30	6.6
	Grade 2	7	10.4	-	-		0	0	-	-		3	4.5	0	0			2	3.0	5	1.1
	Grade 3	0	0	-	-		0	0	-	-		1	1.5	0	0			1	1.5	0	0
	Grade 4	-	-	-	-		0	0	-	-		0	0	0	0			0	0	0	0

^*Adjusted for age, sex, race (White vs. others)

FEV1= forced expiratory volume in one second, DLCOcorr= diffusion capacity of lungs for carbon monoxide corrected for hemoglobin, TLC= total lung capacity

^†Not assessed among controls

^‡Assessed among survivors who consented to semen analysis (n=25)