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. 2020 Aug 27;12(8):639–652. doi: 10.1007/s13238-020-00773-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Consistent intrinsic electrophysiological phenotypes of RTT neurons after ventralization. (A) Schematic representation of dorsal/ventral and anterior/posterior identity in response to patterning morphogens of WNT and SHH. (B) Changes in the expression of dorsoventral (D-V) and but not anteroposterior (A-P) markers assessed by qPCR after ventralization of hiPSC-derived NPCs by SHH treatment. (C) Quantification comparing active and passive membrane properties between WT and MuT neurons with SHH treatment. n (WT1) = 24 neurons; n (WT2) = 22 neurons; n (MuT1) = 19 neurons; n (MuT2) = 29 neurons. Error bars stand for standard error. ***P < 0.001