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. 2021 Jul 24;23:200. doi: 10.1186/s13075-021-02575-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Oxylipin profile is different in PsA patients by enthesis involvement. A PLS-DA scores plot of PsA patients with enthesitis (N = 11) versus PsA patients without enthesitis (N = 8). The explained variances for each component are shown in brackets. B Important features identified by PLS-DA. The colored boxes on the right indicate the relative concentrations of the corresponding metabolite in each group under study. C Heatmap performed using the important features identified by PLS-DA which shows different patterns in the 2 groups. D Precursor assignment for the oxylipins that are decreased (blue rectangle) in PsA patients with enthesitis compared to the group without enthesitis; the oxylipins that are increased in PsA patients with enthesitis compared to the group without enthesitis are indicated by a red rectangle