Figure 1. Differential gene expression in tumor-adjacent stroma (TAS) of Black American and White American PCa patients.

(A) Patient ancestry was determined using LASER (see Materials and Methods). Samples sequenced in our study are indicated in black, those used in our comparisons are encircled. (B) Hierarchical analysis of genes that are differentially expressed in TAS of BA (n = 7) versus WA (n = 7) PCa patients (p_adj < 0.05 and ± 2.5-fold change). Red depicts up- and blue downregulation. Clustered based on genes. N is the number of genes. (C) Overrepresentation of dendritic cell maturation pathways among significantly downregulated genes in the TAS of BA (n = 7) compared to WA (n = 7) prostate cancer patients. Y-axis represents normalized log₂ signal values (normalized reads) (p_adj < 0.05).