Fig. 4.

Taxonomical and functional alterations of gut microbiome. A. The abundance changes of representative taxonomical groups. Significance is indicated by: (Mann-Whitney U test, ∗q < 0.05, ∗∗q < 0.01, ∗∗∗q < 0.01). B. Associations between altered host proteins and gut microbiome taxonomical groups. Only correlations with q < 0.05 were indicated with colored squares. Positive correlations were shown in red and negative correlations were shown in blue, with sizes of squares representing the magnitude of the correlations. C. Volcano plots illustrate biological processes of microbial proteome that were significantly different (q < 0.05) indicated on top of the plot. D. Reduced NADH peroxidase in bacterial species and genera belonging to order Clostridiales (Wilcoxon's rank sum test, ∗q < 0.05, ∗∗q < 0.01, ∗∗∗q < 0.001). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)