Table 2.
Studies on screening characteristics of UtA-PI (at ≥ 95th percentile) at 11–14 weeks of gestation for PE and GH
| N | (n/N%) Prevalence of PE | 95th percentile | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR + | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GH | PE | EOPE | PE | EOPE | FGR | PE | EOPE | PE | EOPE | PE | ||||
| Martin et al. [3] | 3045 | 1.5 | 2.35 | – | 27 | 50 | 95.4 | 95.1 | – | 11 | 4.5 | 99.8 | – | |
| Gomez et al. [4] | 999 | 2.2 | – | 24 | 30 | 50 | 95.1 | – | 95.4 | 11.3 | – | 97.9- | – | – |
| Pilalis et al. [5] | 893 | 2.1 | 2.52 | – | 23 | 60 | – | – | – | 6.7 | – | – | – | – |
| Cnossen et al. [19] | 4966 (PE low risk) | – | – | – | 25 | – | 95 | – | – | – | – | 5.4 | – | 5.4 |
| 433 (PE low risk) | – | – | – |
SPE 40 |
– |
SPE 90 |
– | – | – | – |
SPE 4 |
– | SPE4 | |
|
3045 (FGR low risk) |
– | – | – | – | – | – | – | 75 | – | – | – | – | – | |
| 999 (FGR low risk) | – | – | – | – | – | – | SFGR 95 | – | – | – | – | – | ||
| 785 (high risk) | – | – | – | – | – | – | – | 76 | – | – | – | – | – | |
| Poon et al. [14] | 7977 | 2.9 | 2.45 | 18 | 36* | 37–84* | – | – | – | – | – | – | – | – |
| Napolitano et al. [6] | 6221 | 2.9 | – | 20.7 | – | – | – | – | – | – | – | – | – | |
| Woschitz et al. [20] |
139 (high risk) |
18 | 2.5 | – | 22 | – | 88 | – | – | 29 | – | – | – | – |
| Marcolin et al. [17] | 162 (low risk) | 9.25 | – | – | – | – | – | – | – | – | – | – | – | – |
| Yasmin Casmod et al. [16] | 144 (low risk) | 5.8 | 2.7 | – | – | – | – | – | – | – | – | – | – | – |
| Neravi et al. [21] | 100 (low risk) | 22(45% of these had severe PE) | With preeclampsia the mean PI at 12–16 weeks was 0.9573 and at 24–26 weeks was 0.7968, which was statistically significant (p < 0.0001) as compared to non-preeclamptic women. Hence along with uterine artery diastolic notching and UtA-RI, UtA-PI can be used as a Doppler index for detecting preeclampsia | |||||||||||
| Abdel Moety GAF et al. [22] | 100 (low risk) | – | 2.37 | – | 100 | – | 56 | – | – | – | – | – | – | – |
| Present study | 100 | 9 | 2.8 | 20 | 77.7 | 83.3 | 98.9 | 97.87 | 94.25 | 87.5 | 71.42 | 97.8 | 98.2 | 70.7 |
N = sample size; n = total affected cases; SPE severe preeclampsia; SFGR severe fetal growth retardation;* The estimated detection rate of EOPE, for a 5% false positive rate, was increased from 37% in screening by maternal factors alone to 78% with combined screening by maternal factors and biophysical markers. This was further improved to 84% with serum PAPP-A. However, there was no significant positive contribution from addition of serum PAPP-A to maternal factors, MAP and UtA−lowest PI in the prediction of late PE and GH