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. 2021 Jul 14;147(9):2507–2534. doi: 10.1007/s00432-021-03710-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The chemical structures of Cannabigerol (CBG), Cannabidiol (CBD), Tetrahydrocannabinol (Δ⁹-THC), Cannabichromene (CBC) and Cannabinol (CBN)-type neutral, varinic and acidic phytocannabinoids. More than 120 phytocannabinoids have been isolated from Cannabis sativa L. which can be distinguished into eleven chemical subtypes (Gonçalves et al. 2020; ElSohly 2017). Their common chemical features include a dibenzopyran ring and a hydrophobic alkyl chain (Morales et al. 2017). Aside from Δ⁹-THC and CBD, there has been a current focus on the therapeutic properties of some minor, varinic and acidic cannabinoids (Andre et al. 2016; Franco et al. 2020). Created with BioRender.com