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. 2021 Jul 12;12:717192. doi: 10.3389/fphar.2021.717192

TABLE 4.

Top 10 high-cited original articles in the research scope of intranasal administration.

Ranking Title Total citations Journal First author Year
1 Oxytocin increases trust in humans 2,047 Nature Kosfeld M. 2005
2 Oxytocin modulates neural circuitry for social cognition and fear in humans 1,075 J. Neurosci Kirsch P. 2005
3 Oxytocin improves “mind-reading” in humans 849 Biol. Psychiatry Domes G. 2007
4 Intranasal insulin therapy for alzheimer disease and amnestic mild cognitive impairment a pilot clinical trial 760 Arch. Neurol Craft S. 2012
5 Oxytocin shapes the neural circuitry of trust and trust adaptation in humans 741 Neuron Baumgartner T. 2008
6 Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain 614 Mol. Ther Zhuang X. 2011
7 Exosomes as drug delivery vehicles for Parkinson’s disease therapy 573 J. Control Release Haney M. J. 2015
8 Intranasal insulin improves cognition and modulates beta-amyloid in early AD 539 Neurology Reger M. A. 2008
9 Intranasal insulin improves memory in humans 479 Psychoneuroendocrinology Benedict C. 2004
10 Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype 434 Neurobiol. Aging Reger M. A. 2006