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. 2021 Jul 14;27(26):4208–4220. doi: 10.3748/wjg.v27.i26.4208

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Comparison of the cytotoxicities of norcantharidin (NCTD), NCTD-loaded metal-organic framework IRMOF-3, and NCTD-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel. The inhibitory effect of norcantharidin (NCTD)-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel (NCTD-IRMOF-3-Gel) (C) on Hepa1-6 cells was stronger than that of NCTD (A) and NCTD-loaded metal-organic framework IRMOF-3 (NCTD-IRMOF-3) (B) and showed a certain sustained-release effect.