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. 2021 Jul 14;27(26):4208–4220. doi: 10.3748/wjg.v27.i26.4208

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effects of norcantharidin-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel on the cell cycle. The percentage of total cells in S and G2/M phases increased significantly with increasing norcantharidin (NCTD)-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel (NCTD-IRMOF-3-Gel) concentration, and the proportion of cells in G0/G1 phase decreased significantly. A: Control group; B: 10 μg/mL; C: 20 μg/mL; D: 40 μg/mL. G1 phase: DNA presynthetic phase, where mitosis is complete before DNA replication begins; G2 phase: DNA synthesis replication phase, where DNA replication is complete before mitosis begins; M phase: Cell division phase; S phase: DNA synthesis replication phase.