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. 2021 Jul 12;15:695138. doi: 10.3389/fnins.2021.695138

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Copyright © 2021 Lohkamp, Kiliaan, Shenk, Verweij and Wiesmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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After right transient middle cerebral artery occlusion (tMCAO), mice were randomly allocated into a running wheel (RW) group and a no running wheel (NRW) group. RW mice had 24/7 access to voluntary exercise, while control mice had no running wheel in the cage. Activity/walking patterns of each mouse was individually monitored in digital ventilated cages (DVC) 24/7 for 1 week. Moreover, an open field test was performed to further investigate locomotion and activity. Immediately after MRI scanning, animals were sacrificed and brains were obtained to perform post-mortem immunohistochemistry (IHC), biochemical analysis (BCA), and polarized light imaging (PLI).