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. 2021 Jul 12;15:695138. doi: 10.3389/fnins.2021.695138

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Copyright © 2021 Lohkamp, Kiliaan, Shenk, Verweij and Wiesmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical staining for IBA-1 in brains of mice with (RW) and without a running wheel (NRW) performed 1 week after stroke induction. (A) Representative images of the IBA-1 staining in the ipsilateral (R: right) and contralateral (L: left) hemisphere of bregma –1.94 and 0.62 in RW and NRW animals. (B) Number of IBA-1+ positive cells and (C) relative IBA-1+ area in different ROI (BGG: basal ganglia, C: cortex, CC: corpus callosum, H: hippocampus, TH: thalamus) were calculated. RW: N = 5, NRW: N = 4; values represented in mean ± SEM. ^#0.05 < p < 0.08 (tendency); *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.