Table 4.
miRNAs That Are Validated to Target Differentially Regulated Genes in AA Women with Breast Cancer From the Ambs Group (Martin et al., 2009)
| Gene Symbol | Gene Name | Up- or Downregulated in AA | Validated miRNAs | Intronic miRNAs |
|---|---|---|---|---|
| PSPHP1 (PSPHL) | Phosphoserine phosphatase pseudogene 1 | Up (Epithelium and Stroma) | 0 | |
| AMFR | Autocrine motility factor receptor | Up (Epithelium) | miR-376a-5p, miR-29a/b/c-3p |
|
| EDG2 (LPAR1) | Lysophosphatidic acid receptor 1 | Down (Epithelium) | miR-200c-3p, miR-23a-3p |
|
| CXCL10 | C-X-C motif chemokine ligand 10 | Up (Stroma) | miR-21 | |
| SLC38A1 | Solute carrier family 38 member 1 | Up (Stroma) | miR-16-5p, miR-30a-5p |
|
| PSMA2 | Proteasome subunit alpha 2 | Up (Stroma) | miR-132-3p | |
| LASS6 (CERS6) | Ceramide synthase 6 | Up (Stroma) | 0 | MIR4774 |
| SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | Up (Stroma) | miR-124-3p | |
| ARF4 | ATP ribosylation factor 4 | Up (Stroma) | miR-1-3p, miR-7-5p | |
| GGCT (C7orf24) | Gamma-glutamylcyclotransferase | Up (Stroma) | Let-7b-5p | |
| PTRF | Polymerase 1 and transcript release factor | Down (Stroma) | miR-124-3p | |
| NUAK1 | NUAK family kinase 1 | Down (Stroma) | miR-211-5p | |
| AQP1 | Aquaporin 1 | Down (Stroma) | miR-320a |
Validated miRs are based on those annotated in miRTarBase 2016 with either one or more strong evidence and two or more less strong evidence (Chou et al., 2016).