Table 1.
Demographic characteristics of the whole cohort and subgroups before and after weighted propensity score analysis
| Whole cohort | Before weighted PPS analysis | p value | After weighted PPS analysis | p value | ||
|---|---|---|---|---|---|---|
| Conventional strategy period 2014 | Restrictive strategy period 2015 | Conventional strategy period 2014 | Restrictive strategy period 2015 | |||
| n = 738 | n = 803 | n = 1539.427 | n = 1541.373 | |||
| Age, years, mean (± SD) | 56.21 (18.49) | 55.40 (19.32) | 0.53 | 55.63 (18.67) | 55.7 (19.25) | 0.924 |
| SAPS II, mean (± SD) | 42.2 (21.08) | 39.57 (22.03) | < 0.01 | 40.71 (20.90) | 40.78 (22.2) | 0.928 |
| Diabetes | 220 (29.8) | 207 (25.8) | < 0.01 | 424.923 (27.6) | 427.796 (27.8) | 0.925 |
| Chronic renal insufficiency | 78 (10.6) | 102 (12.7) | 0.19 | 173.641 (11.3) | 177.866 (11.5) | 0.821 |
| Immunosuppression | 48 (6.5) | 89 (11.1) | < 0.01 | 133.373 (8.7) | 136.391 (8.8) | 0.856 |
| Antibiotherapy in the last 3 months | 288 (39.0) | 304 (37.9) | 0.64 | 593.102 (38.5) | 593.741 (38.5) | 0.997 |
| MDR bacteria carrier at ICU admission a | 51 (6.9) | 68 (8.5) | 0.25 | 116.09 (7.5) | 118.888 (7.7) | 0.857 |
| Sepsis (at ICU admission or acquired during ICU stay) | 380 (51.5) | 327 (40.7) | < 0.001 | 706.351 (45.9) | 706.214 (45.8) | 0.970 |
| Invasive mechanical ventilation > 48 h | 438 (59.3) | 364 (45.3) | < 0.001 | 802.415 (52.1) | 802.174 (52.0) | 0.964 |
| Subgroup of antibiotherapy | n = 427 | n = 376 | n = 802.348 | n = 803.804 | ||
|---|---|---|---|---|---|---|
| Age, years, mean (± SD) | 57.24 (17.53) | 56.11 (18.93) | 0.538 | 56.55 (17.63) | 56.65 (18.80) | 0.908 |
| SAPS II, mean (± SD) | 44.94 (21.12) | 44.51 (22.54) | 0.688 | 44.40 (21.63) | 44.49 (22.22) | 0.935 |
| Diabetes | 136 (31.9) | 95 (25.3) | 0.04 | 233.098 (29.1) | 235.304 (29.3) | 0.922 |
| Chronic renal insufficiency | 51 (11.9) | 48 (12.8) | 0.724 | 96.529 (12.0) | 98.767 (12.3) | 0.876 |
| Immunosuppression | 32 (7.5) | 53 (14.1) | < 0.01 | 84.614 (10.5) | 84.99 (10.6) | 0.985 |
| Antibiotherapy in the last 3 months | 242 (56.7) | 230 (61.2) | 0.197 | 472.742 (58.9) | 474.143 (59.0) | 0.978 |
| MDR bacteria carrier at ICU admission a | 42 (9.8) | 46 (12.2) | 0.278 | 85.660 (10.7) | 87.590 (10.9) | 0.867 |
| Sepsis (at ICU admission or acquired during ICU stay) | 372 (87.1) | 315 (83.8) | 0.179 | 685.882 (85.5) | 687.384 (85.5) | 0.986 |
| Invasive mechanical ventilation > 48 h | 309 (72.4) | 228 (60.6) | < 0.001 | 535.210 (66.7) | 536.928 (66.8) | 0.969 |
| Subgroup of septic shock | n = 172 | n = 156 | n = 325.179 | n = 329.259 | ||
|---|---|---|---|---|---|---|
| Age, years, mean (± SD) | 60.88 (13.85) | 62.91 (14.44) | 0.183 | 61.77 (13.36) | 61.92 (14.93) | 0.892 |
| SAPS II, mean (± SD) | 54.69 (22.19) | 54.22 (22.77) | 0.980 | 54.73 (22.59) | 54.48 (22.80) | 0.884 |
| Diabetes | 64 (37.2) | 48 (30.8) | 0.219 | 113.156 (34.8) | 115.746 (35.2) | 0.924 |
| Chronic renal insufficiency | 24 (14.0) | 24 (15.4) | 0.714 | 48.133 (14.8) | 51.222 (15.6) | 0.788 |
| Immunosuppression | 17 (9.9) | 31 (19.9) | 0.011 | 46.225 (14.2) | 47.780 (14.5) | 0.914 |
| Antibiotherapy in the last 3 months | 95 (55.2) | 111 (71.2) | 0.003 | 200.219 (61.6) | 205.274 (62.3) | 0.839 |
| MDR bacteria carrier at ICU admission a | 15 (8.7) | 31 (19.9) | 0.004 | 41.819 (12.9) | 45.429 (13.8) | 0.724 |
| Invasive mechanical ventilation > 48 h | 149 (86.6) | 108 (69.2) | < 0.001 | 257.203 (79.1) | 258.344 (78.5) | 0.843 |
When not specified, results are n (%).
PPS propensity score, SAPS II Simplified Acute Physiology Score II; MRSA methicillin-resistant Staphylococcus aureus, ESBL-E: Extended-spectrum beta-lactamase-producing Enterobacteriaceae, MDR multidrug resistant, SD standard deviation.
aMultidrug-resistant bacteria including ESBL-E and MRSA.