Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Isotope editing pinpoints a single T atom in two DNA duplexes. (A) Sequence of A6-DNA with the labeled T (T9) in red. (B) Chemical structure of N1-methyladenine (m1A) incorporated at A16, opposite the 13C2-labeled T (red). Methyl group on the adenine N1 has a steric clash with the T N3–H, resulting in the purine flipping over into its Hoogsteen form. (C) Light minus heavy difference spectra of A6-DNA (black) and m1A-A6-DNA (blue).
