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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Br J Pharmacol. 2021 Jan 13;178(4):983–996. doi: 10.1111/bph.15341

Figure 6. Sex-dependent effects of auditory fear extinction training on endocannabinoid brain levels.

Figure 6.

AEA and 2-AG brain levels (pmol/g tissue and nmol/g tissue, respectively) in the amygdala (AMY; A, B; for AEA and 2-AG: males No-Ext, n = 10, males Ext, n = 11, females No-Ext, n = 10, females Ext, n = 10), prefrontal cortex (PFC; C, D; for AEA and 2-AG: males No-Ext, n = 10, males Ext, n = 11, females No-Ext, n = 10, females Ext, n = 10), dorsal periaqueductal grey (dPAG; E, F; for AEA and 2-AG: males No-Ext, n = 8, males Ext, n = 9, females No-Ext, n = 9, females Ext, n = 9) and ventral periaqueductal grey (vPAG; G, H; for AEA and 2-AG: males No-Ext, n = 8, males Ext, n = 11, females No-Ext, n = 8, females Ext, n = 10) in male and female rats immediately after the extinction training session (Ext group) or in control groups only exposed to the extinction context without the CS presentations (No-Ext group). Data are expressed as mean ± SEM. * P < 0.05.