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. 2021 Jul 12;9:687856. doi: 10.3389/fcell.2021.687856

FIGURE 4.

FIGURE 4

Rapamycin blocks the ITR-induced cellular morphological changes in mouse patellar tendons. H&E staining shows the normal elongated shape of the tendon cells in cage control (A–C) and rapamycin injected mouse tendons (D–F, white arrows in C,F). Many round shape cells are present in ITR tendons (G-I; yellow arrows in I). With rapamycin injection prior to ITR, markedly fewer round shaped cells are shown in the tendon tissues (J–L). Semi-quantification analysis indicates that more than 55% of the cells in ITR tendon, but less than 10% of the cells in ITR + Rapa treated tendons are round (M). Note that * denotes ITR compared to control, # denotes ITR + Rapa compared to ITR (*p < 0.05, #p < 0.05). Green bar: 500 μm; Yellow bars: 100 μm; Black bars: 25 μm.