Table 3.
Biomarkers | Groups | Unadjusteda | Adjustedb | Adjustedc | ||||
---|---|---|---|---|---|---|---|---|
MetS status | High biomarker ratio | Hazard ratiosa | 95% confidence interval | Hazard ratiosb | 95% confidence interval | Hazard ratiosc | 95% confidence interval | |
UACR | Yes | No | 1.00 (REF) | – | 1.00 (REF) | – | 1.00 (REF) | – |
No | No | 0.52 | 0.44 to 0.61 | 0.96 | 0.81 to 1.13 | 0.97 | 0.80 to 1.16 | |
No | Yes | 2.13 | 1.65 to 2.77 | 2.03 | 1.56 to 2.63 | 2.00 | 1.49 to 2.68 | |
Yes | Yes | 3.17 | 2.54 to 3.95 | 2.46 | 1.94 to 3.11 | 2.32 | 1.76 to 3.05 | |
BUN-CR | Yes | No | 1.00 (REF) | – | 1.00 (REF) | – | 1.00 (REF) | – |
No | No | 0.50 | 0.42 to 0.59 | 0.91 | 0.77 to 1.08 | 0.92 | 0.76 to 1.11 | |
No | Yes | 0.81 | 0.61 to 1.06 | 0.95 | 0.71 to 1.27 | 0.91 | 0.66 to 1.26 | |
Yes | Yes | 1.67 | 1.29 to 2.16 | 1.14 | 0.88 to 1.48 | 1.04 | 0.75 to 1.43 | |
GGT-ALP | Yes | No | 1.00 (REF) | – | 1.00 (REF) | – | 1.00 (REF) | – |
No | No | 0.46 | 0.40 to 0.54 | 0.89 | 0.76 to 1.04 | 0.93 | 0.78 to 1.12 | |
No | Yes | 0.67 | 0.49 to 0.92 | 1.10 | 0.80 to 1.52 | 1.13 | 0.80 to 1.59 | |
Yes | Yes | 0.95 | 0.73 to 1.25 | 1.12 | 0.85 to 1.48 | 1.30 | 0.95 to 1.78 | |
AST-ALT | Yes | No | 1.00 (REF) | – | 1.00 (REF) | – | 1.00 (REF) | – |
No | No | 0.46 | 0.39 to 0.53 | 0.85 | 0.73 to 1.00 | 0.87 | 0.73 to 1.04 | |
No | Yes | 1.03 | 0.79 to 1.34 | 1.46 | 1.13 to 1.89 | 1.47 | 1.11 to 1.96 | |
Yes | Yes | 3.07 | 2.20 to 4.27 | 1.89 | 1.40 to 2.57 | 1.82 | 1.28 to 2.57 |
Data derived from NHANES 1999–2015; referent group has prevalent MetS. Covariates include age, sex, ethnicity, education, income ratio, alcohol use, smoking, hospital visits, insurance coverage, self-rated health, and physical activity
aUnadjusted model of the analytic subsample (n = 10,604); n = 1215 deaths
bFully adjusted model of the analytic subsample (n = 10,604); n = 1215 deaths
cFully adjusted model of a subsample without self-reported CVD, diabetes, or hypertension (n = 9909); n = 970 deaths