Skip to main content
. 2021 Jul 26;21:352. doi: 10.1186/s12872-021-02160-w

Table 3.

Association between all-cause mortality and kidney or liver biomarker ratio without or with MetS (referent)

Biomarkers Groups Unadjusteda Adjustedb Adjustedc
MetS status High biomarker ratio Hazard ratiosa 95% confidence interval Hazard ratiosb 95% confidence interval Hazard ratiosc 95% confidence interval
UACR Yes No 1.00 (REF) 1.00 (REF) 1.00 (REF)
No No 0.52 0.44 to 0.61 0.96 0.81 to 1.13 0.97 0.80 to 1.16
No Yes 2.13 1.65 to 2.77 2.03 1.56 to 2.63 2.00 1.49 to 2.68
Yes Yes 3.17 2.54 to 3.95 2.46 1.94 to 3.11 2.32 1.76 to 3.05
BUN-CR Yes No 1.00 (REF) 1.00 (REF) 1.00 (REF)
No No 0.50 0.42 to 0.59 0.91 0.77 to 1.08 0.92 0.76 to 1.11
No Yes 0.81 0.61 to 1.06 0.95 0.71 to 1.27 0.91 0.66 to 1.26
Yes Yes 1.67 1.29 to 2.16 1.14 0.88 to 1.48 1.04 0.75 to 1.43
GGT-ALP Yes No 1.00 (REF) 1.00 (REF) 1.00 (REF)
No No 0.46 0.40 to 0.54 0.89 0.76 to 1.04 0.93 0.78 to 1.12
No Yes 0.67 0.49 to 0.92 1.10 0.80 to 1.52 1.13 0.80 to 1.59
Yes Yes 0.95 0.73 to 1.25 1.12 0.85 to 1.48 1.30 0.95 to 1.78
AST-ALT Yes No 1.00 (REF) 1.00 (REF) 1.00 (REF)
No No 0.46 0.39 to 0.53 0.85 0.73 to 1.00 0.87 0.73 to 1.04
No Yes 1.03 0.79 to 1.34 1.46 1.13 to 1.89 1.47 1.11 to 1.96
Yes Yes 3.07 2.20 to 4.27 1.89 1.40 to 2.57 1.82 1.28 to 2.57

Data derived from NHANES 1999–2015; referent group has prevalent MetS. Covariates include age, sex, ethnicity, education, income ratio, alcohol use, smoking, hospital visits, insurance coverage, self-rated health, and physical activity

aUnadjusted model of the analytic subsample (n = 10,604); n = 1215 deaths

bFully adjusted model of the analytic subsample (n = 10,604); n = 1215 deaths

cFully adjusted model of a subsample without self-reported CVD, diabetes, or hypertension (n = 9909); n = 970 deaths