Table 1.
Genome-wide studies of dental caries
| Study | Sample size | Dental caries phenotype | Genes | Genome-wide significant associations |
|---|---|---|---|---|
| Shaffer et al. 2011 | 1305 white children, age 3–12 | Binary affection status in primary dentation | ACTN2, EDARADD, MPPED2, MTR, and LPO | No |
| Wang et al. 2012 |
7443 whites Adult, age 17–89 |
Permanent decayed, missing, filled surfaces index (DMFS) | RPS6KA2, ISL1, TLR2 RHOU, FZD1, PTK2B, and ADMTS3, | No |
| Shaffer et al. 2013 |
920 whites Adult, ages 18–75 |
Permanent cluster- based partial DMFS | LYZL2, AJAP1 | Yes |
| ABCG2, PKD2, the dentin/bone SCPP sub-family, EDNRA, TJFBR1, NKX2-3, IFT88, TWSG1, IL17D, and SMAD7 | No | |||
| Zeng et al. 2013 |
1017 whites Adult, age 14–56 |
Permanent decayed and filled teeth (dft) stratified to generate df-pitt and fissures (dfPF)and df-smooth surface (dfSM) | BCOR, BCORL1, INHBA, CXCR1 and CXCR2 | No |
| Zeng et al. 2014 | 1006 white children, age 3–14 | Primary decayed and filled teeth (dft) stratified to generate df-pitt and fissures (dfPF)and df-smooth surface (dfSM) | KPNA4, ITGAL, PLUNC family genes | Yes |
| MPPED2, AJAP, and PRS6KA2 | No | |||
| Haworth et al. 2018 |
19,003 Primary analysis; 13,353 Permanent analysis European ancestry meta-analysis age 2.5–18 |
Presence or absence of treated or untreated caries | ALLC, NEDD9 for primary and permanent dentition respectively | Yes |
| Shungin et al. 2019 | GLIDE and UKB (n = 26,792) | DMFS, DFSS, Nteeth | C5orf66, CA12 | Yes |
| KRTCAP2, WNT10A, FGF10, HLA, FOXL1, PBX3, MAMSTR | No |