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. 2021 Jul 19;32(13-14):682–693. doi: 10.1089/hum.2020.281

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© Sook Hyun Chung et al., 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 4. — T cell-mediated immune responses against AAV8 and GFP after suprachoroidal injection. (A, B) Line plots compare IFN-γ-producing T cell response against AAV8 capsid and GFP transgene in PBMCs before and after bilateral suprachoroidal (SC/SC), suprachoroidal/subretinal (SC/SR), or bilateral intravitreal (IVT/IVT) AAV8 injections. (C, D) Bar plots compare IFN-γ-producing T cell response against AAV8 capsid and GFP transgene from splenocytes collected at necropsy, as indicated by the corresponding colored arrows for each animal. IFN-γ, interferon gamma; SC, suprachoroidal; SFU, spot-forming unit; SR, subretinal. Color images are available online.