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. 2021 Jul 19;32(13-14):744–760. doi: 10.1089/hum.2020.216

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© Anna Stornaiuolo et al., 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 3. — Characterization of CD44v6.CAR T cells used for functional analysis. (A) CAR expression in transduced T lymphocytes detected with the anti-LNGFR mAb C40-1457. Plots of a representative experiment are shown on the left. On the right, means with SDs of the results obtained with eight independent donors are shown. Paired t-test on LNGFR expression was statistically significant for CD44v6-NWN2 (p ≤ 0.05) and CD44v6-NMS (p ≤ 0.05) compared with CD44v6-NWL cells. (B) T cell memory phenotype was defined based on CD45RA and CD62L expression at day 10 after transduction. Plots of a representative donor are shown on the left. On the right, means with SDs of the results obtained with eight independent donors are shown. Paired t-test on T_SCM was statistically significant for untransduced (UT; p ≤ 0.0001), CD44v6-NWN2 (p ≤ 0.001), CD44v6-NMS (p ≤ 0.001), and CD19-NWL (p ≤ 0.01) cells, compared with CD44v6-NWL cells. T_SCM (CD45RA⁺/CD62L⁺ memory stem T cells), T_CM (CD45RA⁻/CD62L⁺ central memory T cells), T_EM (CD45RA⁻/CD62L⁻ effector memory T cells), T_EMRA (CD45⁺/CD62L⁻ effector memory RA T cells). Color images are available online.