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. 2021 Jul 19;32(13-14):744–760. doi: 10.1089/hum.2020.216

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© Anna Stornaiuolo et al., 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 6. — Differentiation status influences the cytotoxic activity of CD44v6.CAR T cells. CD44v6.CAR T cells (NWL, NWN2, and NMS) and CD19-NWL.CAR T cells were kept early differentiated (A) or in vitro differentiated (C) with IL2 (100 U/mL) and OKT-3 (30 ng/mL), and their memory phenotype was defined by CD45RA and CD62L expression. T_SCM (CD45RA⁺/CD62L⁺ memory stem T cells), T_CM (CD45RA⁻/CD62L⁺ central memory T cells), T_EM (CD45RA⁻/CD62L⁻ effector memory T cells), T_EMRA (CD45⁺/CD62L⁻ terminally differentiated T cells). Results obtained from a representative donor are shown. Cytotoxic activity of the early differentiated (B) or differentiated (D) CAR T cells was analyzed after 24 h of coculture with the MR232, MM.1S, and IGROV-1 target cells at the indicated E:T ratio. Results obtained from a representative experiment out of two from independent donors are shown. Color images are available online.