Figure 1.

A. fumigatus airway infection induces the production of IL-1α and IL-1β. C57BL/6 mice were infected intratracheally with sterile agar beads (Sham) or agar beads containing A. fumigatus conidia (AfB). (A) Pulmonary fungal burden as measured by galactomannan Platelia™ ELISA at the indicated time points after infection with A. fumigatus-containing beads. (B) Pulmonary ex vivo IL-1 cytokine secretion as determined by ELISA one and three days after infection. Results are presented as the means ± SEM of groups of at least 7 mice across 2 experiments, *, ** and *** indicates significantly different as compared with Sham mice, p ≤ 0.05, p ≤ 0.01 and p ≤ 0.001 respectively (one-way ANOVA t-test). n.s., not significant.