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. 2021 Jul 12;12:675294. doi: 10.3389/fimmu.2021.675294

Figure 2.

Figure 2

Loss of IL-1 receptor signaling results in increased susceptibility to A. fumigatus airway infection. (A) PAS stained tissue sections of lungs from wild-type or IL-1R1-/- mice 3 days after infection with A. fumigatus-containing beads. (B) Relative hyphal bead density as measured by average intra-bead pixel intensity in ImageScope. Results represent means ± SEM of 16 beads from 3 different mice, ***p ≤ 0.001 (Student’s t-test). (C) Pulmonary fungal burden of C57BL/6 and IL-1R1-/- or (D) C57BL/6 mice treated with IL-1Ra 3 days after infection with A. fumigatus beads. Fungal burden was measured by galactomannan EIA. Results represent the means ± SEM of groups of at least 9 mice across 2 experiments, ***p ≤ 0.001 (Student’s t-test).