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IL-1 receptor-deficient mice exhibit reduced chemokine production and increased leukocyte cell death during A. fumigatus airway infection. (A) Pulmonary ex vivo CXCL1 cytokine secretion as determined by ELISA three days after infection. Results represent means ± SEM of groups of n ≥ 7 mice across 2 experiments, ***p ≤ 0.001 (Student’s t-test). (B) H&E stained tissue sections of lungs from C57BL/6 or IL-1R1-/- mice 3 days after infection with A. fumigatus-containing beads.
