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. 2021 Jul 22;20:15347354211031646. doi: 10.1177/15347354211031646

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Huaier inhibits proliferation, migration and invasion of SCL-1 and A431 cells by promoting the expression of CDKN2A and TP53. SCL-1 cells were transfected with si-CDKN2A or si-TP53 or si-NC, and the modified SCL-1 cells were then treated with 16 mg/mL of Huaier. (A) CCK-8 assay was performed to detect proliferation of SCL-1 cells. (B) Wound-healing assay was performed to examine migration of SCL-1 cells. (C) Transwell invasion assay was performed to assess invasion of SCL-1 cells. A431 cells were transfected with si-CDKN2A or si-TP53 or si-NC, and the modified A431 cells were then treated with 8 mg/mL of Huaier. (D) CCK-8 assay was performed to detect proliferation of A431 cells. (E) Wound-healing assay was performed to examine migration of A431 cells. (F) Transwell invasion assay was performed to estimate invasion of A431 cells.

*P < .05, **P < .01, versus control; ^#P < .05, ^##P < .01, versus si-NC.