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. Author manuscript; available in PMC: 2021 Jul 26.
Published in final edited form as: J Thromb Haemost. 2020 Dec 3;19(2):429–443. doi: 10.1111/jth.15162

FIGURE 8.

FIGURE 8

Effect of treatment of baboons with anti-CD14 antibody on circulating pro- and anti-inflammatory cytokines in the LD100 model of Escherichia coli sepsis. Time course evaluation of cytokines in plasma (A) tumor necrosis factor (TNF), (B) interleukin (IL)-6, (C) IL-1, (D) IL-8, (E) monocyte chemoattractant protein-1 (MCP-1), (F) granulocyte-macrophage colony stimulating factor (GM-CSF), (G) IL-17a, (H) interferon (IFN)γ, (I) IL-1RA, and (J) IL-10 during E coli sepsis with or without anti-CD14 treatment. Data are presented as mean ± standard error of the mean. Same time points are compared between LD100 (red) and LD100 + anti-CD14 survivors (S, green) and non-survivors (NS, black) using multiple t-tests with Holm-Sidak correction for multiple comparisons. *P < .05, **P < .01, ***P < .001, ****P < .0001. Black asterisks mark significant differences between (S) and (NS); green asterisks, between LD100 and (S); and red asterisks, between LD100 and (NS)