Table 4.
Genotype and allele frequencies of polymorphisms in women submitted controlled ovarian hyperstimulation for IVF with normal ovarian response (NOR) and poor ovarian response (POR)
| Polymorphism | Population studied | N | Genotypesb | p valuea | Allelesb | OR (95% CI) | p value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | ||||||
|
GDF9
(398-39; C to G) |
NOR POR |
52 13d |
CC 40 (76.9%) 4(30.8%) |
CG 10 (19.2%) 8(61.5%) |
GG 2 (3.8%) 1(7.7%) |
.006 |
C 90(86.5%) 16(61.5%) |
G 14 (13.5%) 10 (38.5%) |
4.01(1.52-10.60) | 0.005 |
|
GDF9
(C447T) |
NOR POR |
52 14 |
CC 10(19.2%) 7 (50.0%) |
CT 24(46.2%) 5 (35.7%) |
TT 18(34.6%) 2 (14.3%) |
.049 |
C 44(42.3%) 19(67.9%) |
T 60(57.7%) 9(32.1%) |
0.34 (0.14-0.84) | 0.019 |
|
GDF9
(G546A) |
NOR PORW |
52 14 |
GG 37(69.2%) 11(78.6%) |
GA 15(28.8%) 2 (14.3%) |
AA 1(1.9%) 1(7.1%) |
.362 |
G 89(85.6%) 24(85.7%) |
A 17(16.4%) 4(14.3%) |
0.87 (0.26-2.83) | 0.821 |
|
GDF9
(G646A) |
NOR POR |
52 14 |
GG 52(100) 14(100) |
AG - - |
AA - - |
.c |
G - - |
A - - |
.c | |
|
FSHR
(Asn680Ser) |
NOR POR |
52 14 |
NN 18(34.6%) 2(14.3%) |
NS 25(48.1%) 10(71.4%) |
SS 9(17.3%) 2(14.3%) |
.259 |
N 61(58.7%) 14(50.0%) |
S 43(41.3%) 14(50.0%) |
1.41(0.61-3.27) | 0.410 |
|
LH
(Trp8Arg) |
NOR POR |
52 14 |
TT 45(86.5%) 13(92.9%) |
TC 7(13.5%) 1(7.1%) |
CC 0(0) 0(0) |
.520 |
T 97(93.3%) 27(96.4%) |
C 7(6.7%) 1(3.6%) |
0.51(0.06-4.35) | 0.541 |
|
LH
(Ile15Thr) |
NOR POR |
52 14 |
TT 45(86.5%) 13(92.9%) |
TC 7(13.5%) 1(7.1%) |
CC 0(0) 0(0) |
.520 |
T 97(93.3%) 27(96.4%) |
C 7(6.7%) 1(3.6%) |
0.51(0.06-4.35) | 0.541 |
|
LHR
(18isnLQ) |
NOR POR |
52 14 |
NN 31(61.5%) 9(64.5%) |
NV 18(34.6%) 4(28.6%) |
VV 2(3.8%) 1(7.1%) |
.903 |
N 80(78.4%) 22(78.5%) |
V 22(21.6%) 5(21.5%) |
0.82(0.28-2.43) | 0.729 |
|
AMH
(Ile49Ser) |
NOR POR |
52 14 |
TT 30(57.7%) 5(35.7%) |
TG 21(40.4%) 8(57.1%) |
GG 1(1.9%) 1(7.1%) |
.206 |
T 81(77.9%) 18(64.3%) |
G 23(22.1%) 10(35.7%) |
1.95(0.79-4.81) | 0.144 |
|
AMH-R2
(A to G) |
NOR POR |
52 14 |
AA 41(78.8%) 9(64.3%) |
AG 11(21.1%) 4(28.6%) |
GG 0(0) 1(7.1%) |
.117 |
A 93(89.4%) 22(78.5%) |
G 11(10.6%) 6(21.5%) |
2.30(0.76-6.91) | 0.136 |
|
BMP15
(9C>G) |
NOR POR |
52 14 |
CC 33(63.5%) 8(57.1%) |
CG 16(30.8%) 6(42.9%) |
GG 3(5.8%) 0(0) |
.506 |
C 82(78.9%) 22(78.5%) |
G 22(21.1%) 6(21.5%) |
1.01(0.36-2.81) | 0.975 |
a
Monte Carlo test
b
C: cytosine, T: thymine, A: adenine, G: guanine
c
No statistics are computed because GDF9 G646A is a constant
d
There was one less case in this group due to failure of DNA sequencing.