Table 2. Univariable and multivariable Cox regression analyses of the IBPS and correlations with OS in the TCGA cohort.

Variable	Overall survival
	Univariate Cox				Multivariate Cox
	p value	HR	95% CI		p value	HR	95% CI
Age
≥62 vs <62	0.0075	1.6050	1.1350-2.2700		0.0009	1.8900	1.2976-2.7528
Sex
Male vs Female	0.1760	1.2780	0.8954-1.8250		0.4200	1.1630	0.8055-1.6800
Histological type
NOS
Signet ring cell type	0.0565	2.0307	0.9806-4.2054		0.6783	1.1780	0.5438-2.5505
Diffuse type	0.2685	0.7689	0.4827-1.2247		0.1812	0.7087	0.4278-1.1741
Mucinous type	0.0152	0.2395	0.0755-0.7592		0.0206	0.2520	0.0785-0.8094
Papillary type	0.5446	1.4284	0.4507-4.5277		0.1640	2.4470	0.6940-8.6276
Tubular type	0.2558	0.7702	0.4910-1.2083		0.7323	0.9184	0.5640-1.4957
TNM stage
I
II	0.1857	1.5830	0.8017-3.1280		0.1553	1.6560	0.8260-3.3188
III	0.0144	2.2300	1.1734-4.2380		0.0170	2.2790	1.1584-4.4817
IV	0.0004	3.6980	1.7921-7.6310		0.0005	3.8550	1.7978-8.2680
NA	0.0002	5.1930	2.1954-12.2840		0.0008	4.7050	1.9007-11.6448
Grade
1
2	0.4690	1.6870	0.4097-6.9480		0.2812	2.2500	0.5148-9.8341
3	0.2910	2.1300	0.5240-8.6590		0.1229	3.2190	0.7289-14.2170
NA	0.2280	2.8420	0.5201-15.5360		0.0662	5.4690	0.8923-33.5155
Risk score
Increasing	<0.0001	2.4650	1.7420-3.4880		<0.0001	2.3050	1.5836-3.3562

IBPS, immune gene set-based prognostic signature; HR, hazard ratio; CI, confidence interval.