Table 3. Univariable and multivariable Cox regression analyses of the IBPS and correlations with OS in the GSE84437 cohort.

Variable	Overall survival
	Univariate Cox				Multivariate Cox
	p value	HR	95% CI		p value	HR	95% CI
Age
≥62 vs <62	0.0022	1.5387	1.1670-2.0290		0.0007	1.6171	1.2235-2.1370
Sex
Male vs Female	0.1660	1.2395	0.9151-1.6790		0.2367	1.2038	0.8854-1.6370
T stage
1
2	0.9463	0.9474	0.1968-4.5610		0.7378	0.7624	0.1577-3.7330
3	0.1904	2.5859	0.6238-10.7200		0.4621	1.7180	0.4016-7.2680
4	0.0547	3.9247	0.9729-15.8330		0.2187	2.4322	0.5900-10.0260
N stage
0
1	0.1020	1.4487	0.9287-2.2600		0.2378	1.3131	0.8354-2.0640
2	<0.0001	2.9315	1.8826-4.5650		0.0004	2.2971	1.4547-3.6270
3	<0.0001	3.7702	2.1294-6.6750		0.0027	2.4691	1.3683-4.4550
Risk score
Increasing	<0.0001	1.8140	1.3730-2.3970		0.0037	1.5264	1.1474-2.0310

IBPS, immune gene set-based prognostic signature; HR, hazard ratio; CI, confidence interval.