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. 2021 Mar 26;13(13):17118–17136. doi: 10.18632/aging.202773

Table 3. Correlations between upregulated DEGs and gene markers of necroptosis, pyroptosis, ferroptosis and anti-inflammatory in skin tissues.

Mechanism	Gene marker	DCN		COX7A1		COL3A1
Mechanism	Gene marker	R	P	R	P	R	P
Necroptosis	Casp8	0.25	^***	–0.063	0.14	0.27	^***
Necroptosis	RIPK1	0.24	^***	–0.067	0.11	0.093	^*
Pyroptosis	IL-1α	–0.2	^***	–0.23	^***	–0.031	0.46
Pyroptosis	Casp1	–0.12	^**	–0.21	^***	0.28	^***
Ferroptosis	GPX4	0.46	^***	0.67	^***	0.18	^***
Ferroptosis	NCOA4	0.32	^***	–0.096	^*	0.19	^***
Anti-inflammatory	IL-4	0.12	^**	0.05	0.24	0.15	^***
Anti-inflammatory	IL-10	0.36	^***	0.32	^***	0.11	^*