Table 4. Effects of APOE and SORL1 rs3737529 on the age at the midpoint of cognitive function decline (M) and the rate of cognitive function decline (R) parameters based on the MMSE after Bayesian variable selection (n = 299).
Covariates | Minor allele | Regression coefficients on M | Regression coefficients on R | |||
Posterior mean | 95% CI | Posterior mean | 95% CI | |||
Sex (female vs. male) | — | −1.05 | (−3.00, 0.94) | 0.61 | (0.12, 1.12)* | |
Education years | — | 0.38 | (0.18, 0.59)* | −0.04 | (−0.10, 0.01) | |
APOE | ε4 | −2.79 | (−4.46, −1.09)* | 0.93 | (0.44, 1.49)* | |
SORL1 rs3737529 | T | 1.53 | (0.02, 3.04)* | 0.41 | (0.02, 0.87)* |
Note: The full sample of 255 AD and 44 MCI patients at baseline were analyzed.
Abbreviations: MMSE, Mini-Mental State Examination; CI, credible interval.
*Statistically significant with 95% credible interval.