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. 2021 Jul 6;13(13):17190–17201. doi: 10.18632/aging.203169

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Copyright: © 2021 Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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BMSCs-derived exosomes inhibited osteogenesis via miR-424-5p/WIF1. The WIF1 overexpressed plasmid was transfected into BMSCs-derived exosomes. (A–C) The expression of OPN, OCN and Runx2 were compared by qRT-PCR. (D) ALP staining was used to examine ALP activity. (E) Western blot was applied to determine the protein expression of OPN, OCN and Runx2. (F) The protein expression of WIF1/Wnt/β-catenin was verified by western blot. **P<0.01, ***P<0.001 (vs. Con(Exo)). &&P<0.01, &&&P<0.001 (vs. OP(Exo)+PCDNA-NC).