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. 2021 Jul 12;11:667650. doi: 10.3389/fonc.2021.667650

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Copyright © 2021 Tian, Li, Liu, Li, Song, Zheng, Gao, Wen, Su and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plots of the risk of hypothyroidism for grades 3-5. (A) The risk of hypothyroidism calculated by the random effect (RE) model (PD-1/PD-L1 VS. Chemotherapy): subgroup analysis was conducted based on PD-1/PD-L1 and tumor types in both groups. (B) The risk of hypothyroidism calculated by the random effect (RE) model (PD-1/PD-L1 VS. Placebo): subgroup analysis was conducted based on PD-1/PD-L1 and tumor types in both groups. (C) The risk of hypothyroidism calculated by the random effect (RE) model (PD-1/PD-L1+Chemotherapy VS. Chemotherapy): subgroup analysis was conducted based on PD-1/PD-L1 and tumor types in both groups.