Table 6.

COSMIN Risk of Bias Assessment–Generalizability^a

Generalizability Box	Cevidanes et al.25				Cevidanes et al.16				Nada et al.12				DeCesare et al.7				Gkantidis et al.21				Weissheimer et al.3
	E	G	F	P	E	G	F	P	E	G	F	P	E	G	F	P	E	G	F	P	E	G	F	P
Was the sample in which the HR-PRO instrument was evaluated adequately described? In terms of:
Median or mean age (with standard deviation or range)?				x				x	x							x	x				x
Distribution of sex?				x				x				x				x	x							x
Important disease characteristics (e.g., severity, status, duration) and description of treatment?		x				x				x						x	x					x
Setting(s) in which the study was conducted (e.g., general population, primary care or hospital/rehabilitation care)?		x					x			x				x					x			x
Countries in which the study was conducted?			x				x		x						x				x					x
Language in which the HR-PRO instrument was evaluated?			x				x					x			x				x					x
Was the method used to select patients adequately described (e.g., convenience, consecutive, or random)?			x				x				x				x				x				x
Was the percentage of missing responses (response rate) acceptable?			x				x				x				x				x				x

^aCOSMIN box with four-point scale for methodological quality: E, excellent; G, good; F, fair; P, poor. Generalizability box is used to extract data on the characteristics of the study population and sampling procedure, with no scoring system used.24 COSMIN indicates Consensus-Based Standards for the Selection of Health Measurement Instruments. HR-PRO, health-related patient-reported outcome.