KEY RESOURCES

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological Samples
Serum from patients who underwent curative HCC resection (optimization set)	Toranomon Hospital	N/A
Serum from patients with cirrhosis (validation set 1)	University of Michigan	N/A
Serum from patients with or without HCC after hepatitis C virus cure (validation set 2)	Toranomon Hospital	N/A
Serum from patients with HCV-related liver fibrosis consecutively treated with DAA and achieving SVR after curative HCC treatment (validation set 3)	Toranomon Hospital	N/A
Critical Commercial Assays
Human Magnetic Luminex Assay	R&D	Cat No. LXSAHM
Bio-Plex 200 systems	BioRad	171000201
Deposited Data
Serum protein abundance data	This manuscript	http://dx.doi.org/10.17632/5r7c48xkbw.1
Human liver biopsy specimens from HCV, early-stage liver cirrhosis, microarray	Hoshida et al.	GEO Accession GSE15654
Human non-tumor liver tissues from patients with HBV-related HCC undergoing surgical resection, microarray	Roessler et al.	GEO Accession GSE14520
Human liver biopsy specimens from NASH, microarray	Moylan et al.	GEO Accession GSE49541
Human liver biopsy specimens from alcohol-related cirrhosis, microarray	Trepo et al.	GEO Accession GSE94417
Human non-tumor liver tissues from patients with HCV-related HCC undergoing surgical resection, microarray	Tsuchiya et al.	GEO Accession GSE17856
Human liver specimens from patients with HCV infection, microarray	Archer et al.	GEO Accession GSE17967
Human liver biopsy specimens after HCV cure with DAA, microarray	Meissner et al.	GEO Accession GSE51699
Human liver biopsy specimens after hepatitis virus cure with direct-acting antivirals, microarray	Meissner et al.	GEO Accession GSE70779
Human non-tumor liver tissues from patients with HCC undergoing surgical resection, microarray	Kim et al.	GEO Accession GSE39791
Human non-tumor liver tissues from patients with HBV-related HCC undergoing surgical resection, microarray	Halgand et al.	GEO Accession GSE47197
Human non-tumor liver tissues from patients with HCC undergoing surgical resection, microarray	Chaisaingmongkol et al.	GEO Accession GSE76297
Human non-tumor liver tissues from patients with HCC undergoing surgical resection, microarray	Grinchuk et al.	GEO Accession GSE76427
Human non-tumor liver tissues from patients with HBV-related HCC undergoing surgical resection, microarray	Zhou et al.	GEO Accession GSE83148
Human non-tumor liver tissues from patients with HCC undergoing surgical resection, microarray	Wang et al.	GEO Accession GSE84044
Human non-tumor liver tissues from patients with HBV-related HCC undergoing surgical resection, microarray	Hui et al.	GEO Accession GSE121248
Human liver biopsy specimens of different phases from control to NASH, microarray	Ahrens et al.	GEO Accession GSE48452
Human liver biopsy specimens from adolescents undergoing bariatric surgery, microarray	Xanthakos et al.	GEO Accession GSE66676
Human liver biopsy specimens of different phases from control to NAFLD, microarray	Arendt et al.	GEO Accession GSE89632
Human liver biopsy specimens from obese patients, microarray	Francque et al.	GEO Accession GSE83452
Human non-tumor liver tissues from patients with HCC undergoing surgical resection, microarray	Makowska et al.	GEO Accession GSE64041
Software and Algorithms
R (ver. 3.6.1)	CRAN	https://cran.r-project.org/
MSigDB v6.2	Broad Institute	https://www.gsea-msigdb.org/gsea/msigdb/
TexSEC (Translation of tissue gene expression to secretome)	This manuscript	www.texsec-app.org
eseach	Nakagawa et al.	http://www.gparc.org/