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. 2021 Jul 12;12:693066. doi: 10.3389/fmicb.2021.693066

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Copyright © 2021 Weitzel, Vegge, Pane, Goldman, Koshy, Porsby, Burguière and Schoeni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analytical procedure comparison using the analytical target profile (ATP) and tolerance intervals (TI). The white arrow represents the specification range required by the ATP for the analytical procedure to be fit for use. The light gray arrow (AP 1) represents the tolerance interval for one analytical procedure. The dark gray arrow (AP 2) represents the tolerance interval for the second analytical procedure. (A) Comparison showing both procedures perform the same. (B) Comparison showing the tolerance interval for procedure 1 is larger than procedure 2. (C) Comparison showing the two tolerance intervals of the two procedures do not overlap. In all situations both procedures are fit for use.