FIGURE 6.
Postsynaptic neuronal activity in model simulation across 3 paradigms, [Glu]ast = 1.5, 5, and 10 mM. Postsynaptic neuronal membrane is subject to (A) NMDA, AMPA, and GABAA mediated currents with inclusion of astrocytic GAT-3-mediated GABA transport and (B) where the GAT-3-mediated GABA release has been omitted. (i) Postsynaptic neuron membrane potential and (ii) firing frequency as a result of an applied current (pulsed at a frequency of 10 Hz over a 50 s window starting at 20 s). All graphs depict firing frequency calculated using a moving average using window size 1 s, 10% overlap). Inset Figs describe 10 s window (left) for each of the basal [Glu]ast and 2 s window (right) for each basal [Glu]ast, where the time window was selected according to extent of neuronal activity.