FIGURE 7.
Postsynaptic neuronal firing frequency where (A) basal [Glu]ast = 1.5 mM, (B) basal [Glu]ast = 5 mM, and (C) basal [Glu]ast = 10 mM. Within each plot results from the modeling simulation described above were recorded, where inclusion of astrocytic GAT-3 resulted in GABA-mediated activation of GABAA-Rs are either located on both presynaptic and postsynaptic neuronal membrane (solid line), or the postsynaptic neuronal membrane only (dotted line). Exclusion of GAT-3 and thus no GABAA-R mediated currents are included as control (dash-dotted line). In all cases, the inclusion of GABA dynamics resulted in diminished postsynaptic activity, specifically where [Glu]ast = 1.5 mM, which resulted in no postsynaptic activity where GABAA-R activation was considered.