Figure 6.

GLIPH2 analysis of single-cell paired TCR repertoires reveals candidate SARS-CoV-2-specific TCRs. (A) Heatmap shows the proportion of TCR specificity groups containing sequences from specific pairs of patients, as determined by GLIPH2 analysis (total TCR clusters = 552). (B) Bar plot displays the proportions of predicted HLA class I alleles in HLA-attributed TCR specificity groups (total TCR clusters = 552). (C) Graph displays the proportions and numbers of candidate SARS-CoV-2-specific TCRs derived from HLA-A*0201-positive patients, as determined by GLIPH2 clustering with known SARS-CoV-2-specific TCR sequences.