FIG 1.

Adapted epitopes are commonly encoded in the MRKAd5 vaccine inserts. (A) Nef protein sequence encoded by the MRKAd5 vaccine is shown. Bold amino acid residues in red and blue indicate adapted and nonadapted polymorphisms, respectively. Lines underlining amino acid residues represent an adapted (red) or nonadapted (blue) epitope with their respective HLA-I restricting allele given. (B) Proportion of adapted versus nonadapted epitopes encoded within each vaccine immunogen of the MRKAd5 vaccine, and overall, is shown.