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. 2021 Jul;49(7):479–489. doi: 10.1124/dmd.121.000423

TABLE 4.

IC50 values for select compounds on ENT1 and ENT2-mediated [3H]uridine uptake

Data are reported as mean and 95% confidence intervals. A comparison of fits extra sum of squares F test (P ≤ 0.05) was used to compare ENT1 and ENT2 IC50 values for each compound.

Compound ENT1 IC50
µM (95% CI)		 ENT2 IC50
µM (95% CI)		 P
Value
Darunavir 85.98 (47.94,157.50) 8.23 (1.30, 63.03) 0.0116
Mizoribine 2216 (934.80, 6654) 378.2 (197.40, 754.50) 0.0018
Ribavirin 2657 (1213, 7250) 1253 (573.70, 3015) 0.1887