Table 1.

Characteristics of Participant Sample.

	Asymptomatic (N=69)	Symptomatic (N=45)	Total (N=114)	p value
Age				0.095
Mean (SD)	69.5 (6.4)	71.7 (7.5)	70.4 (6.9)
Range	53.0 – 83.0	54.0 – 87.0	53.0 – 87.0
Sex				0.027
Male	21 (30.4%)	23 (51.1%)	44 (38.6%)
Female	48 (69.6%)	22 (48.9%)	70 (61.4%)
Education (Years)				0.172
Mean (SD)	17.1 (2.2)	16.5 (2.5)	16.9 (2.3)
Range	12.0 – 20.0	12.0 – 20.0	12.0 – 20.0
APOE Genotype				0.013
% with 1 or more E4 alleles	25 (36.2%)	27 (60.0%)	52 (45.6%)
Global CDR score				< 0.001
0	64 (94.1%)	0 (0.0%)	64 (57.1%)
0.5	4 (5.9%)	34 (77.3%)	38 (33.9%)
1	0 (0.0%)	6 (13.6%)	6 (5.4%)
2	0 (0.0%)	4 (9.1%)	4 (3.6%)
MTL White Matter ROI (FA)				< 0.001
Mean (SD)	0.41 (0.03)	0.38 (0.03)	0.40 (0.03)
Range	0.32 – 0.49	0.31 – 0.44	0.31 – 0.49
AD Vulnerable White Matter ROI (FA)				< 0.001
Mean (SD)	0.47 (0.02)	0.44 (0.02)	0.46 (0.03)
Range	0.40 – 0.51	0.40 – 0.50	0.40 – 0.51
Abeta42 (pg/mL)				0.067
Mean (SD)	10.2 (2.2)	9.4 (2.4)	9.9 (2.3)
Range	5.4 – 16.2	5.9 – 16.2	5.4 – 16.2
Tau (pg/mL)				0.003
Mean (SD)	2.0 (0.5)	2.5 (0.9)	2.2 (0.7)
Range	1.1 – 3.8	1.1 – 4.9	1.1 – 4.9
NFL (pg/mL)				< 0.001
Mean (SD)	13.8 (6.7)	21.4 (9.4)	16.8 (8.7)
Range	5.3 – 52.1	7.7 – 44.1	5.3 – 52.1
GFAP (pg/mL)				< 0.001
Mean (SD)	148.1 (72.7)	265.9 (125.6)	194.6 (112.5)
Range	50.0 – 449.4	65.2 – 633.6	50.0 – 633.6
SENAS Memory Composite Score				< 0.001
Mean (SD)	0.9 (0.6)	−0.4 (0.8)	0.4 (0.9)
Range	−0.8 – 2.4	−2.7 – 1.5	−2.7 – 2.4
Spatial Composite Score				< 0.001
Mean (SD)	1.1 (0.7)	−0.3 (1.3)	0.5 (1.2)
Range	−0.7 – 2.4	−2.9 – 2.3	−2.9 – 2.4
Executive Composite Score				< 0.001
Mean (SD)	0.6 (0.5)	−0.3 (0.6)	0.2 (0.7)
Range	−0.6 – 1.7	−1.8 – 0.7	−1.8 – 1.7
Language/Semantic Composite Score				< 0.001
Mean (SD)	1.9 (0.7)	0.8 (0.9)	1.4 (0.9)
Range	0.4 – 3.2	−1.9 – 3.4	−1.9 – 3.4

^*MTL= medial temporal lobe; WM=white matter; FA= fractional anisotropy