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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Neurobiol Aging. 2021 Feb 26;103:68–77. doi: 10.1016/j.neurobiolaging.2021.02.012

Table 4.

Estimated (Est) regression coefficients investigating GFAP, white matter microstructure, and verbal memory.

Outcome Predictor Est.a Std. Error P-value Adj. Est.b Std. Error P-value
Associations between GFAP and white matter microstructure
 MTL ROI GFAP −0.0094 0.0028 0.0012 −0.0014 0.0032 0.65
 AD Vulnerability ROI GFAP −0.0050 0.0024 0.041 0.0015 0.0027 0.58
 CST ROI GFAP 0.0014 0.0028 0.62 0.0022 0.0035 0.52
Associations between white matter microstructure and verbal memory
 Verbal Memory MTL ROI 12.6 2.6 <0.0001 4.8 2.5 0.053
 Verbal Memory AD Vulnerability ROI 12.8 3.2 0.00011 4.3 2.9 0.13
 Verbal Memory CST ROI 0.33 3.0 0.91 0.18 2.3 0.94
Joint association between GFAP, white matter microstructure and verbal memory
 Verbal Memory GFAP −0.42 0.0072 <0.0001 −0.25 0.077 0.002
MTL ROI 8.4 2.3 0.001 4.5 2.4 0.061
 Verbal Memory GFAP −0.45 0.07 <0.0001 −0.26 0.077 0.001
AD Vulnerability ROI 9.3 2.8 0.001 4.9 2.7 0.08
 Verbal Memory GFAP −0.50 0.072 <0.0001 −0.26 0.078 0.001
CST ROI 1.2 2.5 0.64 0.64 2.2 0.77
a

Regression coefficients adjusted for age, gender and education.

b

Regression coefficients adjusted for age, gender, education, APOE E4 status, and symptomatic/asymptomatic.

CST= corticospinal tract