Figure 1.

Drug sensitivities for primary and secondary mutations in GIST. Colors denote drug sensitivity: green indicates sensitive, orange indicates sensitivity depends on experimental conditions, red indicates resistant, and red/green hatching indicates that the sensitivity is dependent on the amino acid change. ^aApproved TKIs are sensitive to non D842V, but only avapritinib and, to some degree, ripretinib are potent against the PDGFRA exon 18 D842V mutation. AV, avapritinib; GIST, gastrointestinal stromal tumors; IM, imatinib; PDGFRA, platelet-derived growth factorreceptor a; RE, regorafenib; RI, ripretinib; SU, sunitinib; TK1, tyrosine kinase domain 1; TK2, tyrosine kinase domain 2.