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. Author manuscript; available in PMC: 2021 Jul 26.
Published in final edited form as: Cell Rep. 2021 Jul 6;36(1):109338. doi: 10.1016/j.celrep.2021.109338

Figure 5. Mutations of GluN2A Ser-1459 result in prolonged excitatory postsynaptic currents (EPSCs) in heterosynapses.

Figure 5.

(A) Examples of EPSCs together with normalized, averaged current overlays (top, right) mediated by GluN1/2AWT (blue), GluN1/2AS1459A (orange), GluNI/2AS1459D (green), and GluN1/2AS1459G (red).

(B–D) Summary box-and-whisker plots of mean synaptic current peak amplitudes (B), mean 10%–90% activation times (C), and mean decay time constants (D) for the indicated receptors. Boxes indicate the median, 25th, and 75th percentiles, and the whiskers mark the minimum and maximum values (WT, n = 19 cells; S1459A, n = 12; S1459D, n = 18; and S1459G, n = 30). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 using one-way ANOVA with a Dunnett’s multiple comparison test.