Table 2.
Intraocular Pressure and Medication Data at Each Time Point
| Baseline | Day 1 | Week 1 | Month 1 | Month 3 | Month 6 | Month 12 | Month 24 | |
|---|---|---|---|---|---|---|---|---|
| Number of eyes (n) | 38 | 38 | 38 | 38 | 38 | 38 | 30 | 26 |
| Mean IOP (SD, range) | 24.6 (3.0, 20–32) | 12.6 (2.3, 8–21) | 13.8 (3.3, 10–26) | 14.0 (2.0, 10–18) | 14.2 (2.0, 11–22) | 14.2 (1.5, 10–17) | 14.7 (1.6, 10–18) | 14.9 (2.0, 11–18) |
| Change from baseline (SD) | — | −12.0 (4.0) | −10.8 (4.1) | −10.7 (3.1) | −10.5 (3.5) | −10.4 (3.4) | −10.1 (3.7) | −10.0 (3.2) |
| Percent change from baseline (SD) | — | −47.9 (11.7) | −43.4 (14.3) | −42.8 (9.2) | −41.6 (10.2) | −41.4 (9.5) | −39.8 (10.6) | −39.6 (9.1) |
| Significance | — | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Mean number of IOP- lowering medications (SD, range) | 1.9 (0.7) | 0.1 (0.2, 0–1) | 0 (0) | 0.1* (0.4, 0–2) | 0.2** (0.4, 0–2) | 0.3† (0.6, 0–2) | 0.4†† (0.6, 0–2) | 0.5††† (0.7, 0–2) |
| Change from baseline (SD) | — | −1.8 (0.8) | −1.9(0.7) | −1.8 (0.6) | −1.7 (0.7) | −1.6 (0.9) | −1.4 (1.0) | −1.4 (1.1) |
| Percent change from baseline (SD) | — | −96.1 (17.9) | −100 (0) | −95.2 (14.4) | −92.5 (21.1) | −80.7 (42.5) | −70.6 (48.3) | −64.1 (57.5) |
| Significance | — | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
Notes: *One eye on bimatoprost/timolol fixed combination, 2 eyes on brinzolamide. **One eye on bimatoprost/timolol fixed combination, I eye on bimatoprost, 2 eyes on brinzolamide. †One eye on bimatoprost/timolol fixed combination, one eye on latanoprost/timolol fixed combination, 2 eyes on bimatoprost, 3 eyes on brinzolamide, 2 eyes on dorzolamide. ††One eye on bimatoprost/timolol fixed combination, one eye on latanoprost/timolol fixed combination, 2 eyes on bimatoprost, 1 eye on latanoprost, 5 eyes on brinzolamide, 2 eyes on dorzolamide. †††One eye on bimatoprost/timolol fixed combination, one eye on latanoprost/timolol fixed combination, 2 eyes on bimatoprost, 2 eyes on latanoprost, 1 eye on tafluprost, 1 eye on timolol/dorzolamide fixed combination, 2 eyes on brinzolamide.