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. 2021 Jul 21;15:3207–3221. doi: 10.2147/DDDT.S319260

Figure 1.

Figure 1

BAI administration significantly ameliorates diabetic conditions in db/db mice. (A) Animal experimental protocol of this study. (B) Body weight of mice was recorded every 3 days during the experiment. (n=8) (C) Fasting blood glucose of mice was recorded weekly during the experiment. (n=8) (D) HOMA-IR index was calculated according to standard formula: HOMA-IR= FBG (mM) × fasting insulin (mU/L)/22.5. (n=8) (E) For GTT, mice were fasted overnight and intraperitoneally injected with glucose (i.p., 0.75 g/kg), blood glucose was measured at 0, 15, 30, 60 and 120 min after glucose administration; the bar graph represents average area under the curve. (n=6) (F) For ITT, mice were fasted overnight and intraperitoneally injected with insulin (i.p., 1.0 U/kg), blood glucose was measured at 0, 15, 30, 60 and 120 min after insulin administration; the bar graph represents average area under the curve. (n=6) All data are presented as means ± SD. *p <0.05, **p < 0.01, ***p < 0.001.