Fig. 1. Effect of NOB on food intake (A), energy intake (B), body weight (C, D), fat mass (E), and FER (F) in HCD-fed mice. Values are presented as mean ± SE (n = 12). Values are significantly different between the groups, according to Student's t-test.

ND, normal diet; HCD, high-cholesterol diet (35 kcal% fat, 1.25% cholesterol, 0.5% cholic acid); HCD + NOB, high-cholesterol diet plus nobiletin (0.02%); FER, food efficiency ratio.

^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ND vs. HCD; ^#P < 0.05, ^##P < 0.01, HCD vs. HCD + NOB.